Occurrence and neuroendocrine role ofD-aspartic acid andN-methyl-D-aspartic acid inCiona intestinalis

N-methyl-D-aspartic acid receptor structure and function.

D-Aspartic acid: an endogenous amino acid with an important neuroendocrine role.

D-Aspartic acid (d-Asp), an endogenous amino acid present in vertebrates and invertebrates, plays an important role in the neuroendocrine system, as well as in the development of the nervous system. During the embryonic stage of birds and the early postnatal life of mammals, a transient high concentration of d-Asp takes place in the brain and in the retina. d-Asp also acts as a neurotransmitter...

Paraneoplastic Anti-N-Methyl-D-Aspartic Acid Receptor Encephalitis

Metabolism of L-aspartic acid.

Aspartic acid, like glutamic acid, occupies a central position in amino acid metabolism. In most tissues it takes part in the transamination reaction (1). In the liver and the kidney, where all amino acids undergo cleamination, the rate of this process for aspartic acid is second only to glutamic acid (2). For these reasons, one would expect the exchange of amino nitrogen of aspartic acid with ...

The Synthesis of Aspartic Acid

No one of the methods proposed for the synthesis of aspartic acid is entirely satisfactory as a practical procedure. The synthesis, described in a recent paper (1) from this laboratory, has been utilized in preparing 50 to 60 gm. lots of recrystallized aspartic acid but even here the beginning reagents are expensive, the over-all yield is only about 30 per cent of the theoretical, and the proce...